During the 19th Century, coca – and its psychoactive alkaloid, cocaine – proved increasingly popular in Europe and North America, featuring in drinks, tonics, medicines and various other products. They included Vin Mariani, a French wine with more than 200mg/litre of cocaine. Adverts claimed it "refreshed body and brain" and fans included Thomas Edison, Ulysses S Grant, Emile Zola and Pope Leo XIII (who even appeared on a promotional poster).